A ‘warhorse-shaped’ topology adopted by the m 6 A RNA writer complex

The m(6)A writer complex is a holoenzyme formed by catalytic MAC and regulatory MACOM subcomplexes that play a key role in the readout of this most prevalent epigenetic mark on RNA. Su et al. recently determined the cryo-EM structures of the MACOM complex at high resolution and the MAC-MACOM complex at medium resolution, thereby defining the composition and assembly of the core MACOM complex, as well as highlighting insights into the regulatory mechanism of m(6)A RNA readout at the molecular level and its impact on function.