Refining Therapy in Patients with HER2-Positive Breast Cancer with Central Nervous System Metastasis.

Marta Filipa Freire Vaz Batista,Inês Eiriz,Amanda Fitzpatrick,Fanny Le Du,Sofia Braga,Diogo Alpuim Costa

Breast care (Basel, Switzerland)（2022）

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摘要

The treatment paradigm for patients with HER2+ MBC has changed. Local therapies play an important role, but accumulating evidence on the intracranial activity and clinical benefit of anti-HER2 targeting therapies might lead to a shift in the paradigm on treating BM in the next few years towards more widespread use of systemic therapy.

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关键词

Anti-HER2-targeted therapy,Brain metastasis,Central nervous system metastasis,Human epidermal growth factor receptor-type 2-positive breast cancer,Leptomeningeal carcinomatosis

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