T Cell Repertoire Profiling in Allografts and Native Tissues in Recipients with Covid-19 After Solid Organ Transplantation: Insight Into T Cell-Mediated Allograft Protection from Viral Infection

J. Fu, D. Rust,Z. Fang,W. Jiao,S. Lagana,I. Batal,B. Chen,S. Merl,R. Jones,M. Sykes,J. Weiner

Frontiers in immunology（2023）

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摘要

Our findings suggest a systemic immune response to the SARS-CoV-2 virus in solid organ transplant patients that is not associated with rejection and consistent with a largely destructive effect of recipient HLA-restricted T cell clones that affects donor and native organs similarly.

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关键词

COVID–19,SARS–CoV–2,T cell,T cell repertoire analysis,immune response,immunosuppressed,transplant recipients,viral response

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