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Flexible Strain Sensors Based on an Interlayer Synergistic Effect of Nanomaterials for Continuous and Noninvasive Blood Pressure Monitoring

ACS APPLIED MATERIALS & INTERFACES(2024)

Taiyuan Univ Technol | Univ Texas El Paso

Cited 1|Views16
Abstract
The continuous, noninvasive monitoring of human blood pressure (BP) through the accurate detection of pulse waves has extremely stringent requirements on the sensitivity and stability of flexible strain sensors. In this study, a new ultrasensitive flexible strain sensor based on the interlayer synergistic effect was fabricated through drop-casting and drying silver nanowires and graphene films on polydimethylsiloxane substrates and was further successfully applied for continuous monitoring of BP. This strain sensor exhibited ultrahigh sensitivity with a maximum gauge factor of 34357.2 (∼700% sensitivity enhancement over other major sensors), satisfactory response time (∼85 ms), wide strange range (12%), and excellent stability. An interlayer fracture mechanism was proposed to elucidate the working principle of the strain sensor. The real-time BP values can be obtained by analyzing the relationship between the BP and the pulse transit time. To verify our strain sensor for real-time BP monitoring, our strain sensor was compared with a conventional electrocardiogram-photoplethysmograph method and a commercial cuff-based device and showed similar measurement results to BP values from both methods, with only minor differences of 0.693, 0.073, and 0.566 mmHg in the systolic BP, diastolic BP, and mean arterial pressure, respectively. Furthermore, the reliability of the strain sensors was validated by testing 20 human subjects for more than 50 min. This ultrasensitive strain sensor provides a new pathway for continuous and noninvasive BP monitoring.
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Key words
flexible strain sensor,interlayer synergistic effect,continuous blood pressuremonitoring,wearable sensors,graphene
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要点】:本文提出了一种基于纳米材料层间协同效应的超敏感柔性应变传感器,用于连续无创监测人体血压。

方法】:通过滴铸法将银纳米线与石墨烯膜滴铸在聚二甲基硅氧烷基底上,利用层间断裂机制实现传感器的超高灵敏度。

实验】:实验使用银纳米线与石墨烯膜,通过在聚二甲基硅氧烷基底上滴铸并干燥,制成的应变传感器具有最大量程为12%,响应时间为85 ms,稳定性出色,并在20名受试者身上进行了超过50分钟的测试。结果显示,该传感器测得的血压值与传统心电图-光电容积描记图方法及商用血压计的测量结果相似,收缩压、舒张压和平均动脉压的差异分别为0.693、0.073和0.566 mmHg。