Chronic seizure-induced serotonin pathway dysregulation coincides with mortality in Alzheimer's disease mouse models.

Sudden unexpected death is a devasting consequence of uncontrolled epilepsySerotonin pathway dysfunction may increase risk of premature mortality in epilepsyAPP/PS1 mice are at higher risk of seizure-induced mortality versus other AD modelsSeizures downregulate hippocampal serotonin pathway proteins solely in APP/PS1 miceSeizure-induced mortality in APP/PS1 mice does not require amyloid β accumulation.