Therapeutic potential of green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) in SARS-CoV-2 infection: Major interactions with host/virus proteases

•EGCG inhibits the binding of SARS-CoV-2 spike (S) protein with host ACE2 receptor.•EGCG promotes Nrf2 activation for suppression of ACE2 and TMPRSS2 expression and activity in host cells.•EGCG in vitro prevents SARS-CoV-2 replication and infection in host cells by inhibiting the activities of 3CLpro, PLpro, Nsp15, and RdRp.•EGCG prevents virus-induced cytokine storm, HMGB1 secretion, lung fibrosis and thrombosis-like complications in host cells.