Genomic Alterations and Tumor Mutation Burden in Merkel Cell Carcinoma.

Danielle Brazel,Priyanka Kumar,Hung Doan,Tianyu Pan,Weining Shen,Ling Gao,Justin T Moyers

JAMA network open（2023）

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摘要

In this cross-sectional retrospective study of alterations and TMB in MCC, a minority of patients had potentially actionable alterations. These findings support the investigation of targeted therapies as single agent or in combination with immunotherapy or cytotoxic chemotherapy in selected MCC populations.

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tumor mutation burden,carcinoma,genomic

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