Coagulation status and determinants of possible aspirin resistance in patients with essential thrombocythemia.
Frontiers in medicine(2022)
摘要
Compared with AS patients, AR patients have enhanced platelet aggregation function, are in a relatively hypercoagulable state, and haveelevated fibrinogen function/levels, all of which cause a worse coagulation status. ET patients with increasing age, irregular use of aspirin, smoking, dyslipidemia, and hypertension are possibly at higher risk of AR. The routine NGS may not be helpful for the prediction of AR, therefore we recommend adding relevant drug-resistance genes to NGS.
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关键词
aspirin resistance,clinical features,coagulation status,essential thrombocythemia,next-generation sequencing
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