Lipid peroxidation and sphingolipid alterations in the cerebral cortex and hypothalamus of rats fed a high-protein diet

•A high-protein diet exacerbates lipid peroxidation in the hypothalamus.•A protein diet enhances the ceramide level and sphingomyelin hydrolysis in the hypothalamus.•High protein ingestion has a minor effect on the metabolic profile in the cerebral cortex.