Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 ( CXCL13 ) in Hyperplastic Prostate.

Daoquan Liu,Mingzhou Li,Xun Fu,Shu Yang,Zhen Wang,Jianmin Liu,Yan Li,Yongying Zhou,Pengfei Ren,Yuhang Guo,Xinghuan Wang,Michael E DiSanto,Ping Chen,Xinhua Zhang

International journal of molecular sciences（2022）

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摘要

Our novel data demonstrated that modulated cell proliferation, cell cycle, the EMT of epithelial cells, and induced the fibrosis of prostatic stromal cells via a variety of inflammatory factors, suggesting that might be rediscovered as a potential therapeutic target for the treatment of BPH.

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关键词

CXCL13,benign prostatic hyperplasia,epithelial–mesenchymal transition,fibrosis,inflammation,proliferation

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