Recombinant irisin enhances the extracellular matrix formation, remodeling potential, and differentiation of human periodontal ligament cells cultured in 3D

Yang Yang,Tianxiang Geng,Athina Samara,Ole Kristoffer Olstad,Jianying He,Anne Eriksson Agger,Bjørn Helge Skallerud,Maria A. Landin,Catherine Anne Heyward,Helen Pullisaar,Janne Elin Reseland

Journal of Periodontal Research（2023）

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摘要

Irisin altered the morphology in primary hPDL cell-derived spheroids, enhanced its ECM deposition, mechanical properties, differentiation and remodeling potential.

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关键词

extracellular matrix,irisin,mechanical properties,osteogenesis,periodontal ligament cells,three-dimensional culture

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