Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization.

Haowei Bai,Yanwei Sha,Yueqiu Tan,Peng Li,Yuxiang Zhang,Junwei Xu,Shuai Xu,Zhiyong Ji,Xiaobo Wang,Wei Chen,Jianxiong Zhang,Chencheng Yao,Zheng Li,Erlei Zhi

Frontiers in endocrinology（2022）

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摘要

Our findings support that TAF7L is one of pathogenic genes of OAT and deleterious mutations in TAF7L may cause impaired histone-to-protamine affected the chromatin compaction of sperm head.

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关键词

ICSI,TAF7L,hemizygous variant,male infertility,oligoasthenoteratozoospermia

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