Icariin Has a Synergistic Effect on the Osteoinductivity of Bone Morphogenetic Protein 2 at Ectopic Sites

Xin Zhang,Xingnan Lin,Mingjie Wang,Liquan Deng,Lingfei Wei,Yuelian Liu

Orthopaedic Surgery（2023）

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摘要

The co-administration of Icariin and BMP-2 increased BMD changed the distribution of newly formed bone, and reduced the amount of remaining materials. Therefore, Icariin can stimulate BMP-2 when incorporated into BioCaP granules at ectopic sites, which makes it useful for bone tissue engineering.

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关键词

Biomimetic calcium phosphate,Bone morphogenetic protein 2 (BMP-2),Ectopic sites,Icariin,Osteoinductive

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