EFFECTS OF A GLYPHOSATE-BASED HERBICIDE ON SYSTEMIC METABOLIC ALTERATIONS AND HISTOLOGIC HEPATIC CHANGES PRESENT IN AN ANIMAL MODEL OF INSULIN RESISTANCE

Introduction: oxidative stress and inflammation associated with insulin resistance (IR) contribute to the generation of non-alcoholic steatohepatitis. Also, exposure to glyphosate, a widely used herbicide, increases hepatic lipid peroxidation with increased free radicals of O2. Objectives: to evaluate the effects of the prolonged administration of a herbicide based on glyphosate on the generation of IR, oxidative stress and hepatic histological changes in animals treated with a sucrose rich diet (DRS).