An experimental and theoretical approach of coordination compounds derived from meso-tetra(thiophen-2-yl)porphyrin: DNA interactions and cytotoxicity

George Bueno Santana Pereira,Josias da Silveira Rocha,Mauro Almeida Lima,Gabriela Porto de Oliveira,Rafael Gomes da Silveira,Moacir Rossi Forin,Luciano da Silva Pinto,Kleber Thiago de Oliveira,Fillipe Vieira Rocha

Inorganic Chemistry Communications（2023）

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摘要

•Synthesis, experimental and theoretical characterization.•New insights into the structural and reactivity features of porphyrin complexes.•Evaluation of DNA interactions showed low damage to DNA structure.•The IC50 values of Mn(III) compound surpasses cisplatin towards tested cell lines.

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关键词

Synthesis,Characterization,Metalloporphyrin,Theoretical study,DNA interactions,Cytotoxicity

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