Pancreatic enzyme supplementation versus placebo for improvement of gastrointestinal symptoms in non-responsive celiac disease: A cross-over randomized controlled trial.

Shakira Yoosuf,Caitlin G Barrett,Konstantinos Papamichael,Sarah E Madoff,Satya Kurada,Joshua Hansen,Jocelyn A Silvester,Amelie Therrien,Prashant Singh,Melinda Dennis,Daniel A Leffler,Ciaran P Kelly

Frontiers in Medicine（2022）

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摘要

In this prospective, cross-over randomized, placebo-controlled study, PES did not improve symptoms in patients with NRCD. It is unclear whether this is a trial effect or related to administration of omeprazole.

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关键词

diarrhea,dyspepsia,exocrine pancreatic insufficiency,malabsorption,pancreas,proton pump inhibitors,sprue

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