Stereospecific recognition of a chiral centre over multiple flexible covalent bonds by F-19-NMR

High performance in chiral recognition by a reactive F-19-tag was demonstrated for a variety of enantiomers. The analytes with up to five flexible covalent bonds from the chiral center can be discriminated by a sensitive chiral reporter manifested in the F-19-NMR spectrum. Simultaneous identification of chiral amines in a mixture and high accuracy ee determination were achieved.