Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells.

Aram Lee, Haesun Park,Soyoung Lim,Jihyun Lim,Jaemoon Koh,Yoon Kyung Jeon,Young Yang,Myeong-Sok Lee,Jong-Seok Lim

Journal for immunotherapy of cancer（2023）

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摘要

Our results indicate that MITF regulates the differentiation and function of MDSCs and can be a novel therapeutic target for modulating MDSC activity in immunosuppressive s.

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关键词

biomarkers, tumor,immunomodulation,myeloid-derived suppressor cells,tumor microenvironment

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