Dysfunctional network of hub genes in hypertrophic cardiomyopathy patients.

Shan Wu, Iqtidar Ud Din, Faisal Mahmood Sadiq,Mostafa A Abdel-Maksoud,Muhammad Haris,Ayman Mubarak,Mohamed A Farrag, Sumaiah Alghamdi,Sally Almekhlafi,Muhammad Akram,Guangyao Li

American journal of translational research（2022）

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摘要

Our study revealed that ten hub genes (CD14, ITGB2, C1QB, CD163, HCLS1, ALOX5AP, PLEK, C1QC, FCER1G, and TYROBP) are involved in the development and progression of HCM. These genes can potentially be used as biomarkers and therapeutic targets for HCM patients.

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关键词

Hypertrophic cardiomyopathy,biomarker,hub genes,miRNAs,therapeutic target

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