Partially clustered designs for clinical trials: Unifying existing designs using consistent terminology.

Clinical trials (London, England)(2023)

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摘要
Our findings demonstrate that the description of these trials is often incomplete and the terminology used to describe the trial designs is inconsistent, restricting the ability to identify these trials in the literature. By adopting the definitions and terminology presented in this article, the reporting of partially clustered trials can be substantially improved, and we present several recommendations for reporting these trial designs in practice. Greater awareness of partially clustered trials will facilitate more methodological research into their design and analysis, ultimately improving the quality of these trials.
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关键词
Clinical trials,clustering,group-based treatment,individually randomised group treatment,partial clustering,partial nesting,re-randomisation,reporting guidelines,terminology,trial design
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