Angiotensin Ii Type 1a Receptor Expressed In Smooth Muscle Cells Is Required For Vascular Remodeling In Mice Infused With Angiotensin II

Keiichi Torimoto, Hymavathi Reddy Vari,Keisuke Okuno,Stephanie M. Cicalese,Satoru Eguchi

Hypertension (Dallas, Tex. : 1979)（2023）

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摘要

Smooth muscle AT receptors mediate Ang II-induced vascular remodeling including medial hypertrophy and inflammatory perivascular fibrosis regardless of the presence of hypertension. Our data suggest an independent etiology of blood pressure elevation and hypertensive vascular remodeling in response to Ang II.

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关键词

angiotensin II,fibrosis,hypertension,receptor,vascular smooth muscle cell

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