Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques.

Edith M. Walker,Kristen M. Merino,Nadia Slisarenko,Brooke F. Grasperge,Smriti Mehra,Chad J. Roy,Deepak Kaushal,Namita Rout

Frontiers in immunology（2022）

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摘要

Overall, these data suggest that despite SIV-induced decline in IL-7R expression and IFN-γ production by mycobacterial lipid-reactive T cells, their cytolytic potential is maintained. A deeper understanding of anti-mycobacterial lipid-reactive T cell functions may inform novel approaches to enhance TB control in individuals with or without HIV infection.

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关键词

BCG,SIV,lipid antigen,macaque,tuberculosis,γδT

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