Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development.
Science (New York, N.Y.)(2023)
摘要
Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-γ). Host-derived IFN-γ facilitates Dome1-mediated activation of the JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting vectorial competence. We highlight the evolutionary dependence of on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.
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关键词
vector immunity,parasite,dome1–jak–stat
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