A selfish bacteriocin dictates pneumococcal domination

Efficient colonization of new hosts is critical for survival of Streptococcus pneumoniae. In this issue of Cell Host & Microbe, Aggarwal et al. investigate the population dynamics of this process, demonstrating how a quorum-sensing bacteriocin locus promotes survival of individual clonal lineages, providing a population bottleneck and restricting genetic diversity.