Assessment of Biomarkers of Myocardial injury, Inflammation, and Renal Function in Heart Failure With Reduced Ejection Fraction: The VICTORIA Biomarker Substudy.

Christopher R Defilippi,Wendimagegn G Alemayehu,Adriaan A Voors,David Kaye,Robert O Blaustein,Javed Butler,Justin A Ezekowitz,Adrian F Hernandez,Carolyn S P Lam,Lothar Roessig,Stephen Seliger,Palak Shah,Cynthia M Westerhout,Paul W Armstrong,Christopher M O'Connor

Journal of cardiac failure（2023）

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摘要

hs-cTnT, growth differentiation factor-15, and interleukin-6 levels were associated with risk of the primary outcome in VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction). Uniquely, lower hs-cTnT was associated with a lower rate of cardiovascular death but not HF hospitalization after treatment with vericiguat.

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关键词

Heart failure with reduced ejection fraction,circulating biomarkers,vericiguat

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