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Platinum(terpyridine) Complexes with N-heterocyclic Carbene Co-Ligands: High Antiproliferative Activity and Low Toxicityin Vivo

Dalton transactions(2023)

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摘要
Pt(terpyridine) complexes are well-known DNA intercalators. The introduction of an NHC co-ligand rendered such a complex highly antiproliferative in cancer cells compared to its chlorido derivative. Despite the high potency, zebrafish embryos tolerated the compound well, especially compared to cisplatin. DNA interaction studies support a mode of action related to intercalation.
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