A New Alkaloid Derivative from the Saprophytic Fungus Neohelicomyces Hyalosporus PF11-1

A new alkaloid, neohelicomyine A (1), along with two known alkaloids (2-3), were isolated from the fermentation of Neohelicomyces hyalosporus PF11-1. The structures of these compounds were elucidated by extensive analyses of spectroscopic methods including 1 D and 2 D NMR, HRESIMS and ECD. The bioactivities of all compounds were evaluated using cellular assays, and compounds 2 and 3 displayed moderate cytotoxicities against human cancer (A549, TCA, RD) cells with IC50 values of 26-87 μg/mL.