Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway.

Y E Xiaomei,Xing Xiaowei,Yuan Kangrui,Wang Dongming,W U Dudu,Chen Zhi,Y U Zhiqiang

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan（2023）

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摘要

Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.

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关键词

Astragaloside IV,Glucose consumption,HepG2 cells,Insulin resistance,JNK,ROS

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