New insights from a multi-ethnic Asian progressive supranuclear palsy cohort.

Shen-Yang Lim,Alfand Marl F Dy Closas, Ai Huey Tan,Jia Lun Lim,Yi Jayne Tan,Yuganthini Vijayanathan,Yi Wen Tay, Raihanah Binti Abdul Khalid, Wai Keong Ng, Ruban Kanesalingam,Pablo Martinez-Martin, Azlina Ahmad Annuar,Lei Cheng Lit,Jia Nee Foo,Weng Khong Lim,Adeline Su Lyn Ng,Eng-King Tan

Parkinsonism & related disorders（2023）

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摘要

Significant heterogeneity in clinical features and disease burden, and high rates of RBD symptoms, visual hallucinations, and familial involvement were observed in this relatively large cohort. Our findings highlight important considerations when assessing Asian patients, and provide further support for the notion of overlapping neurobiology between PSP and Lewy body disorders.

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关键词

CADASIL,Caregiver burden,Diagnostic criteria,GBA,Genetics,LRRK2,PSP-CDS,Progressive supranuclear palsy,REM-sleep behaviour disorder,Visual hallucinations,Zarit Burden Interview

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