Predictive Modeling to Assess Pretest Probability of Transthyretin Gene Variants Based on Demographic Information.

Joshua Saef,Trejeeve Martyn,Lauren Ives,Lori R Roth,Justin L Grodin,Mathew S Maurer,Mazen Hanna,W H Wilson Tang

Circulation. Heart failure（2023）

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摘要

This CART algorithm incorporating age, sex, and race was able to determine which patients with ATTR-CM have pathogenic mutations with high specificity. Non-Black patients diagnosed at age 69 years or older with ATTR-CM have a low likelihood to have ATTRv.

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amyloid,amyloidosis,cardiomyopathy,transthyretin

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