IL-37 alleviates intervertebral disc degeneration via the IL-1R8/NF-κB pathway.

Sunlong Li,Xiangxiang Pan,Yuhao Wu,Yiting Tu,Weijun Hong,Jiaping Ren, Jiansen Miao, Tengjie Wang,Weiyi Xia,Jiajie Lu,Jiaoxiang Chen,Xuqi Hu,Yan Lin,Xiaolei Zhang,Xiangyang Wang

Osteoarthritis and cartilage（2023）

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摘要

The present study suggests that IL-37 delays the IDD development through the IL-1R8/NF-κB pathway, which suggests IL-37 as a promising novel target for IDD therapy.

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关键词

IL-1R8,Interleukin-37,Intervertebral disc degeneration,NF-κB pathway,Senescence

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