Delineating Plasmodium liver infection across space and time
Trends in Parasitology（2023）
摘要
The liver is a major entry point and gatekeeper for invasive pathogens. However, high-resolution, spatiotemporal transcriptomic analysis of host-pathogen interactions has remained challenging. Afriat et al. have deconvoluted Plasmodium berghei liver-stage maturation at an unprecedented scale and discovered molecular signatures of heterogeneity during pre-erythrocytic development of malarial parasites.
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关键词
Plasmodium,liver zonation,spatiotemporal transcriptomic analysis,single-cell RNA sequencing,single-molecule fluorescence in situ hybridization,host–parasite interactions
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