SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia.

Courtney Chambers,Katerina Cermakova,Yuen San Chan,Kristen Kurtz,Katharina Wohlan,Andrew Henry Lewis,Christiana Wang, Anh Pham,Milan Dejmek,Michal Sala,Mario Loeza Cabrera,Rogelio Aguilar,Radim Nencka,H Daniel Lacorazza,Rachel E Rau,H Courtney Hodges

Cancer research（2023）

引用 5|浏览19

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摘要

Disruption of PU.1-directed enhancer programs upon SWI/SNF inhibition causes differentiation of AML cells and induces leukopenia of PU.1-dependent B cells and monocytes, revealing the on- and off-tumor effects of SWI/SNF blockade.

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关键词

normal hematopoietic cells,swi/snf

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