Generation of a TIMP3 knockout stem cell line via CRISPR/Cas9 system

Tong Yi,Jingjing Liu,Siyao Zhang,Yihua He,Jiancheng Han

Stem Cell Research（2023）

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摘要

•Generation a homozygous TIMP3 knockout human embryonic stem cell line via CRISPR/Cas9 system.•TIMP3-KO cell line maintained highly pluripotency and normal karyotype.•TIMP3-KO cell line would be used as cell model for SORSBY Fundus Dystrophy.

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crispr/cas9,cell

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