Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma.

Huichao Huang,Fangling Huang,Xujun Liang,Ying Fu,Zhe Cheng,Yan Huang,Zhuchu Chen,Yankun Duan,Yongheng Chen

Pharmaceuticals (Basel, Switzerland)（2022）

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摘要

Collectively, this work identifies the molecular mechanism of afatinib as a radiation sensitizer, thus providing a potentially useful combination treatment and drug target for NPC radiosensitization. Our findings describe a new function of afatinib in radiosensitivity and cancer treatment.

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关键词

CD44-Stat3 signaling pathway,afatinib,epithelial-to-mesenchymal transition (EMT),nasopharyngeal carcinoma (NPC),radiosensitivity

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