Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the "obesity paradox".

Logan V. Vick,Craig P. Collins,Lam T. Khuat,Ziming Wang,Cordelia Dunai,Ethan G. Aguilar,Kevin Stoffel,Sai Yendamuri,Randall Smith,Sarbajit Mukherjee,Joseph Barbi,Robert J. Canter,Arta M. Monjazeb,William J. Murphy

Frontiers in immunology（2022）

引用 2|浏览8

暂无评分

摘要

These results suggest that both aging and obesity contribute to T cell dysfunction resulting in increased thymic involution. This combined with increased T cell exhaustion and immunosuppressive parameters affects immunotherapy efficacy reducing the advantage of obesity in cancer immunotherapy responses.

查看译文

关键词

PD-1,T cell,aging,immunotherapy,inflammaging,obesity,thymic involution

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要