Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.

Rui Lu,Haoran Xu,Xiaofeng Deng,Yingguang Wang,Zhiyi He,Shimeng Xu,Shuang Liang,Xiaojian Huang,Hongbo You,Fengjing Guo,Peng Cheng,An-min Chen

Journal of orthopaedic translation（2023）

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摘要

This study successfully reveals that PA, a natural bioactive withanolide, effectively relieved IVDD progression via inflammation inhibition, fibrosis reduction, and autophagy enhancement, indicating it is a promising agent for IVDD treatment.

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关键词

Autophagy,Fibrosis,Inflammation,Intervertebral disc degeneration,Physalin A

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