Progressive Spread of Beta-amyloid Pathology in an Olfactory-driven Amyloid Precursor Protein Mouse Model

Helen C. Murray,Galit Saar, Li Bai, Nadia Bouraoud,Stephen Dodd, Blake Highet, Brigid Ryan, Maurice A. Curtis, Alan Koretsky,Leonardo Belluscio

Neuroscience（2023）

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摘要

•Spread of human β-amyloid protein from olfactory epithelium to the olfactory bulb in OMP-hAPP mice.•Reduced olfactory bulb volume in OMP-hAPP mice due to APP-mediated disruption of development.•Progressive accumulation of human β-amyloid protein in the piriform cortex and hippocampus of OMP-hAPP mice.•β-amyloid deposition was not accompanied by regional atrophy in OMP-hAPP mice.

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关键词

olfactory bulb,olfactory sensory neurons,anterior olfactory nucleus,Alzheimer’s disease,amyloid precursor protein,β-amyloid

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