Platelets mediate acute hepatic microcirculatory injury in a protease-activated-receptor-4-dependent manner after extended liver resection

Yunjie Zhang,Patrick Huber,Marc Praetner,Alice Zöllner,Lesca Holdt,Andrej Khandoga,Maximilian Lerchenberger

Transplant Immunology（2023）

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摘要

•PAR-4 mediates platelet-neutrophil interactions following extended hepatectomy.•Platelets mediate acute inflammatory processes following extended hepatectomy.•Platelet depletion alleviates liver injury following extended liver resection.

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关键词

Small-for-size syndrome,Platelet,Hepatectomy,Liver microcirculation,Intravital microscopy

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