Distribution of intraperitoneally administered deuterium-labeled water in aquaporin-4-knockout mouse brain after middle cerebral artery occlusion.

Takuya Urushihata,Hiroyuki Takuwa,Manami Takahashi,Jeff Kershaw,Sayaka Shibata,Nobuhiro Nitta,Yasuhiko Tachibana,Masato Yasui,Makoto Higuchi,Takayuki Obata

Frontiers in neuroscience（2022）

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摘要

These results suggest that AQP4 loss affects water dynamics in the ACA region not only in the infarct region. Dynamic PDWI after DO administration may be a useful tool for showing the effects of AQP4 .

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关键词

aquaporin-4,brain ischemia,brain water dynamics,deuterium-labeled water,in vivo proton-density-weighted MRI

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