Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis.

Arjan Boltjes,Anoushka Ashok Kumar Samat,Maud Plantinga,Michal Mokry,Bas Castelijns,Joost F Swart,Sebastiaan J Vastert,Menno Creyghton,Stefan Nierkens,Jorg van Loosdregt,Femke van Wijk

Frontiers in immunology（2022）

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摘要

Our findings suggest that at the site of inflammation, there is specific functional programming of human DCs, especially cDC2. In contrast, the enriched cDC1 remain relatively quiescent and seemingly unchanged under inflammatory conditions, pointing to a potentially more regulatory role.

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关键词

DC quiescence,DC subsets,functional programming,inflammation,juvenile arthritis,synovial fluid

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