Ruxolitinib does not completely abrogate the functional capabilities of TLR4/9 ligand-activated NK cells.

Carmen Mestre-Durán,Carla Martín-Cortázar,Blanca García-Solís,Alicia Pernas, Lidia Pertíñez,Víctor Galán,Luisa Sisinni,Laura Clares-Villa,Alfonso Navarro-Zapata,Karima Al-Akioui,Adela Escudero,Cristina Ferreras,Antonio Pérez-Martínez

Frontiers in immunology（2022）

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摘要

In summary, our results showed that the functional capabilities and phenotype of NK cells activated through TLR4/9 agonists were not completely abolished by the inhibition of the JAK-STAT pathway by ruxolitinib.

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关键词

JAK - STAT signaling pathway,NK cells,TLR pathway,TLR4 ligand,TLR9 ligand,ruxolitinib

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