Metabolic remodeling of glycerophospholipids acts as a signature of dulaglutide and liraglutide treatment in recent-onset type 2 diabetes mellitus.

Juan Du,Liuqing Xi,Zhongxiao Zhang,Xiaoxu Ge,Wenyi Li,Wenfang Peng,Xiaohong Jiang,Wen Liu,Nan Zhao,Xingyun Wang,Xirong Guo,Shan Huang

Frontiers in endocrinology（2022）

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摘要

In total, a metabolic change in lipids existed in the early stage of T2D was ameliorated after the treatments of GLP-1RAs. In addition to similar effects on improving glycemic control, remodeling of glycerophospholipid metabolism was identified as a signature of dulaglutide and liraglutide treatments.

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关键词

Glycerophospholipids,LC-MS,dulaglutide and liraglutide,metabolic remodeling,type 2 diabetes mellitus

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