Association of the risk factor UNC13A with survival and upper motor neuron involvement in amyotrophic lateral sclerosis.

Arianna Manini, Valeria Casiraghi,Alberto Brusati,Alessio Maranzano,Francesco Gentile,Eleonora Colombo,Ruggero Bonetti,Silvia Peverelli,Sabrina Invernizzi,Davide Gentilini,Stefano Messina,Federico Verde,Barbara Poletti,Isabella Fogh,Claudia Morelli,Vincenzo Silani,Antonia Ratti,Nicola Ticozzi

Frontiers in aging neuroscience（2023）

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摘要

Overall, our findings confirm the role of as a determinant of survival in ALS patients and show the association of this locus also with upper motor neuron involvement.

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关键词

UNC13A,alleles,amyotrophic lateral sclerosis,behavioral symptoms,genotype,motor neurons

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