MRSA Isolates from Patients with Persistent Bacteremia Generate Nonstable Small Colony Variants in Vitro Within Macrophages and Endothelial Cells During Prolonged Vancomycin Exposure.

Thiago Fauerharmel-Nunes,Ronald S. Flannagan,Mariya I. Goncheva,Arnold S. Bayer,Vance G. G. Fowler Jr,Liana C. C. Chan,Michael R. Yeaman,Yan Q. Xiong,David E. Heinrichs

INFECTION AND IMMUNITY（2023）

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摘要

Staphylococcus aureus (especially methicillin-resistant S. aureus [MRSA]) is frequently associated with persistent bacteremia (PB) during vancomycin therapy despite consistent susceptibility in vitro . Strategic comparisons of PB strains versus those from vancomycin-resolving bacteremia (RB) would yield important mechanistic insights into PB outcomes.

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关键词

Vancomycin Resistance,MRSA,Multidrug-Resistant Bacteria,Antimicrobial Susceptibility Testing,Bacteremia

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