Evaluation of the procoagulant state in chronic immune thrombocytopenia before and after eltrombopag treatment-a prospective cohort study.

Wobke E M van Dijk,Geke C Poolen,Albert Huisman,Harry R Koene,Rob Fijnheer,Noortje Thielen, Esther R van Bladel,Karin P M van Galen,Roger E G Schutgens,Rolf T Urbanus

Journal of thrombosis and haemostasis : JTH（2023）

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摘要

Patients with ITP in this study were in a hypercoagulable state, with preactivated platelets, increased thrombin generation potential, and increased levels of factor VIII and von Willebrand factor. Eltrombopag treatment further increased plasma thrombin generation potential but no other hemostatic parameters.

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关键词

ITP,TPO-RA,eltrombopag,procoagulant,thrombosis

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