Comparison of integrin α v β 3 expression with 68 Ga-NODAGA-RGD PET/CT and glucose metabolism with 18 F-FDG PET/CT in esophageal or gastroesophageal junction cancers
European journal of hybrid imaging(2023)
摘要
Background The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of 68 Ga-NODAGA-RGD PET/CT with that of 18 F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination. Methods Ten 68 Ga-NODAGA-RGD and ten 18 F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 ± 8.4 y, range 40–69 y). Maximum SUV (SUV max ) and metabolic tumor volumes (MTV) were calculated. The Mann–Whitney U test and Spearman correlation analysis ( ρ ) were used. Results 68 Ga-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph nodes and 3 skeletal sites. 18 F-FDG PET/CT detected positive uptake in the same sites but also in 16 additional lymph nodes and 1 adrenal gland. On a lesion-based analysis, SUV max of 18 F-FDG was significantly higher than those of 68 Ga-NODAGA-RGD (4.9 [3.7–11.3] vs. 3.2 [2.6–4.2] g/mL, p = 0.014). Only one participant showed a higher SUV max in an osseous metastasis with 68 Ga-NODAGA-RGD as compared to 18 F-FDG (6.6 vs. 3.9 g/mL). Correlation analysis showed positive correlation between 18 F-FDG and 68 Ga-NODAGA-RGD PET parameters ( ρ = 0.56, p = 0.012 for SUV max , ρ = 0.78, p < 0.001 for lesion-to-background ratios and ρ = 0.58, p = 0.024 for MTV). We observed that 18 F-FDG uptake was homogenous inside all the confirmed primary sites ( n = 9). In contrast, 68 Ga-NODAGA-RGD PET showed more heterogenous uptake in 6 out of the 9 confirmed primary sites (67%), seen mostly in the periphery of the tumor in 5 out of the 9 confirmed primary sites (56%), and showed slight extensions into perilesional structures in 5 out of the 9 confirmed primary sites (56%). Conclusions In conclusion, 68 Ga-NODAGA-RGD has lower potential in the detection of esophageal or esophagogastric junction malignancies compared to 18 F-FDG. However, the results suggest that PET imaging of integrin α v β 3 expression may provide complementary information and could aid in tumor diversity and delineation. Trial registration: Trial registration: NCT02666547. Registered January 28, 2016—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02666547 .
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关键词
Esophageal cancer,PET,18F-FDG,68Ga-NODAGA-RGD,Integrin α β 3,Angiogenesis
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