Efficacy of maribavir in valganciclovir-resistant cytomegalovirus retinitis.

PURPOSE:To determine whether maribavir is effective at treating ganciclovir-resistant cytomegalovirus retinitis. METHODS:Retrospective case report of a lung-transplant patient with bilateral cytomegalovirus retinitis documented with serum and aqueous humor studies and color fundus photographs. RESULTS:A 72-year-old lung-transplant patient with active ganciclovir-resistant cytomegalovirus was treated with intravitreal foscarnet therapy in one eye. Retinitis developed in the contralateral eye and was managed with systemic maribavir alone. Active retinitis regressed in both the eye treated with intravitreal foscarnet and the uninjected eye. CONCLUSION:This patient's results suggest that systemic maribavir is an effective treatment for treatment-resistant cytomegalovirus retinitis.