The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration.

Yuanchang Hu,Feng Zhan,Yong Wang,Dong Wang,Hao Lu,Chen Wu,Yongxiang Xia,Lijuan Meng,Feng Zhang,Xun Wang,Shun Zhou

Cellular and molecular gastroenterology and hepatology（2023）

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摘要

The Ninj1/Dusp1 axis contributes to liver IR injury by regulating the proinflammatory response of KCs, and influences neutrophil infiltration, partly by subsequent regulation of C-X-C motif chemokine ligand 1 (CXCL1) production after IR.

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关键词

Dual-Specificity Phosphatase 1,Kupffer Cells,Liver IR Injury,Nerve Injury-Induced Protein 1,Sterile Inflammation

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