Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal

Parul Kudtarkar, Maria C. Costanzo,Ying Sun,Dongkeun Jang, Ryan Koesterer,Josyf C Mychaleckyj, Uma Nayak,Suna Onengut-Gumuscu, Stephen S Rich,Jason A Flannick, Kyle J Gaulton,Noël P Burtt

biorxiv(2023)

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摘要
Translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight can reveal novel biology and therapeutic targets but remains a major challenge. We developed the T1D Knowledge Portal (T1DKP), a disease-specific resource of genetic and functional annotation data that enables users to develop hypotheses for T1D-based research and target discovery. The T1DKP can be used to query genes and genomic regions for genetic associations, identify epigenomic features, access results of bioinformatic analyses, and obtain expert-curated resources. The T1DKP is available at . ### Competing Interest Statement KJG holds stock in Neurocrine biosciences and has done consulting for Genentech
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